Mechanical Stimulation of Bone and
Cartilage Cells

      Another area in which he is interested is how skeletal cells (bone and cartilage cell) react to mechanical stress in terms of cell proliferation and matrix metabolism. I plan to study the changes in morphology, biochemical, and biomechanical properties of tissue engineered cartilage over 3 months of in vitro culture with and without the application of compressive force. He propose to test the hypothesis that the tissue engineered cartilage with compressive force reaches normal levels more rapidly than those without compressive force. The change in mechanical properties will be correlated to polymer degradation, new cartilage matrix formation, and histological appearance. This project is with Dr. Karen Hasty, Department of Anatomy and Neurobiology, University of Tennessee, Memphis.

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